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The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

Poly (ADP-ribose) is synthesized at DNA single-strand breaks and can promote the recruitment of the scaffold protein, XRCC1. However, the mechanism and importance of this process has been challenged. To address this issue, we have characterized the mechanism of poly (ADP-ribose) binding by XRCC1 and...

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Detalles Bibliográficos
Autores principales:	Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L., Hanzlikova, Hana, Oliver, Antony W., Caldecott, Keith W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538820/ https://www.ncbi.nlm.nih.gov/pubmed/26130715 http://dx.doi.org/10.1093/nar/gkv623

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