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Probabilistic Voxel-Fe model for single cell motility in 3D

BACKGROUND: Cells respond to a variety of external stimuli regulated by the environment conditions. Mechanical, chemical and biological factors are of great interest and have been deeply studied. Furthermore, mathematical and computational models have been rapidly growing over the past few years, pe...

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Detalles Bibliográficos
Autores principales: Borau, Carlos, Polacheck, William J, Kamm, Roger D, García-Aznar, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538854/
https://www.ncbi.nlm.nih.gov/pubmed/26290806
http://dx.doi.org/10.1186/2196-050X-1-2
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author Borau, Carlos
Polacheck, William J
Kamm, Roger D
García-Aznar, José Manuel
author_facet Borau, Carlos
Polacheck, William J
Kamm, Roger D
García-Aznar, José Manuel
author_sort Borau, Carlos
collection PubMed
description BACKGROUND: Cells respond to a variety of external stimuli regulated by the environment conditions. Mechanical, chemical and biological factors are of great interest and have been deeply studied. Furthermore, mathematical and computational models have been rapidly growing over the past few years, permitting researches to run complex scenarios saving time and resources. Usually these models focus on specific features of cell migration, making them only suitable to study restricted phenomena. METHODS: Here we present a versatile finite element (FE) cell-scale 3D migration model based on probabilities depending in turn on ECM mechanical properties, chemical, fluid and boundary conditions. RESULTS: With this approach we are able to capture important outcomes of cell migration such as: velocities, trajectories, cell shape and aspect ratio, cell stress or ECM displacements. CONCLUSIONS: The modular form of the model will allow us to constantly update and redefine it as advancements are made in clarifying how cellular events take place.
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spelling pubmed-45388542015-08-17 Probabilistic Voxel-Fe model for single cell motility in 3D Borau, Carlos Polacheck, William J Kamm, Roger D García-Aznar, José Manuel In Silico Cell Tissue Sci Article BACKGROUND: Cells respond to a variety of external stimuli regulated by the environment conditions. Mechanical, chemical and biological factors are of great interest and have been deeply studied. Furthermore, mathematical and computational models have been rapidly growing over the past few years, permitting researches to run complex scenarios saving time and resources. Usually these models focus on specific features of cell migration, making them only suitable to study restricted phenomena. METHODS: Here we present a versatile finite element (FE) cell-scale 3D migration model based on probabilities depending in turn on ECM mechanical properties, chemical, fluid and boundary conditions. RESULTS: With this approach we are able to capture important outcomes of cell migration such as: velocities, trajectories, cell shape and aspect ratio, cell stress or ECM displacements. CONCLUSIONS: The modular form of the model will allow us to constantly update and redefine it as advancements are made in clarifying how cellular events take place. 2014-10-01 /pmc/articles/PMC4538854/ /pubmed/26290806 http://dx.doi.org/10.1186/2196-050X-1-2 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Article
Borau, Carlos
Polacheck, William J
Kamm, Roger D
García-Aznar, José Manuel
Probabilistic Voxel-Fe model for single cell motility in 3D
title Probabilistic Voxel-Fe model for single cell motility in 3D
title_full Probabilistic Voxel-Fe model for single cell motility in 3D
title_fullStr Probabilistic Voxel-Fe model for single cell motility in 3D
title_full_unstemmed Probabilistic Voxel-Fe model for single cell motility in 3D
title_short Probabilistic Voxel-Fe model for single cell motility in 3D
title_sort probabilistic voxel-fe model for single cell motility in 3d
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538854/
https://www.ncbi.nlm.nih.gov/pubmed/26290806
http://dx.doi.org/10.1186/2196-050X-1-2
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