Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

Ubiquitination of the epidermal growth factor receptor (EGFR) that occurs when Cbl and Grb2 bind to three phosphotyrosine residues (pY1045, pY1068 and pY1086) on the receptor displays a sharp threshold effect as a function of EGF concentration. Here we use a simple modelling approach together with e...

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Detalles Bibliográficos
Autores principales: Capuani, Fabrizio, Conte, Alexia, Argenzio, Elisabetta, Marchetti, Luca, Priami, Corrado, Polo, Simona, Di Fiore, Pier Paolo, Sigismund, Sara, Ciliberto, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538861/
https://www.ncbi.nlm.nih.gov/pubmed/26264748
http://dx.doi.org/10.1038/ncomms8999

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