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Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

Reactional episodes in leprosy are a result of complex interactions between the immune system, Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we co...

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Autores principales: Cortela, D. C. B., de Souza Junior, A. L., Virmond, M. C. L., Ignotti, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539113/
https://www.ncbi.nlm.nih.gov/pubmed/26339136
http://dx.doi.org/10.1155/2015/548540
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author Cortela, D. C. B.
de Souza Junior, A. L.
Virmond, M. C. L.
Ignotti, E.
author_facet Cortela, D. C. B.
de Souza Junior, A. L.
Virmond, M. C. L.
Ignotti, E.
author_sort Cortela, D. C. B.
collection PubMed
description Reactional episodes in leprosy are a result of complex interactions between the immune system, Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we conducted a systematic review of primary literature published between 1996 and 2013. A three-stage literature search was performed (Stage I, “leprosy reactions” and “inflammatory mediators”; Stage II, “dental infections” and “inflammatory mediators”; and Stage III, “leprosy reactions,” “dental infections,” and “inflammatory mediators”). Of the 911 eligible publications, 10 were selected in Stage I, 68 in Stage II, and 1 in Stage III. Of the 27 studied inflammatory mediators, the main proinflammatory mediators were IL-6, IFN-γ, TNF-α, IL-1β, and IL-17; the main anti-inflammatory mediators were IL-10 and IL-4. Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease. The proinflammatory mediators in dental infections and leprosy reactions, especially IL-6 and TNF-α, were similar across studies, regardless of the laboratory technique and sample type. IFN-γ and IL-1β were significant for leprosy reactions and periodontal diseases. This pattern was maintained in serum.
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spelling pubmed-45391132015-09-03 Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review Cortela, D. C. B. de Souza Junior, A. L. Virmond, M. C. L. Ignotti, E. Mediators Inflamm Review Article Reactional episodes in leprosy are a result of complex interactions between the immune system, Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we conducted a systematic review of primary literature published between 1996 and 2013. A three-stage literature search was performed (Stage I, “leprosy reactions” and “inflammatory mediators”; Stage II, “dental infections” and “inflammatory mediators”; and Stage III, “leprosy reactions,” “dental infections,” and “inflammatory mediators”). Of the 911 eligible publications, 10 were selected in Stage I, 68 in Stage II, and 1 in Stage III. Of the 27 studied inflammatory mediators, the main proinflammatory mediators were IL-6, IFN-γ, TNF-α, IL-1β, and IL-17; the main anti-inflammatory mediators were IL-10 and IL-4. Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease. The proinflammatory mediators in dental infections and leprosy reactions, especially IL-6 and TNF-α, were similar across studies, regardless of the laboratory technique and sample type. IFN-γ and IL-1β were significant for leprosy reactions and periodontal diseases. This pattern was maintained in serum. Hindawi Publishing Corporation 2015 2015-08-03 /pmc/articles/PMC4539113/ /pubmed/26339136 http://dx.doi.org/10.1155/2015/548540 Text en Copyright © 2015 D. C. B. Cortela et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cortela, D. C. B.
de Souza Junior, A. L.
Virmond, M. C. L.
Ignotti, E.
Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review
title Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review
title_full Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review
title_fullStr Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review
title_full_unstemmed Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review
title_short Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review
title_sort inflammatory mediators of leprosy reactional episodes and dental infections: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539113/
https://www.ncbi.nlm.nih.gov/pubmed/26339136
http://dx.doi.org/10.1155/2015/548540
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