γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation

T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. The aim of this study was to evalua...

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Detalles Bibliográficos
Autores principales: Zhang, Weixi, Zhang, Xueya, Sheng, Anqun, Weng, Cuiye, Zhu, Tingting, Zhao, Wei, Li, Changchong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539120/
https://www.ncbi.nlm.nih.gov/pubmed/26339131
http://dx.doi.org/10.1155/2015/258168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539120/
https://www.ncbi.nlm.nih.gov/pubmed/26339131
http://dx.doi.org/10.1155/2015/258168

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