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Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling

The disruption of normal hematopoiesis has been observed in leukemia, but the mechanism is unclear. Osteoblasts originate from bone mesenchymal stem cells (BMSCs) and can maintain normal hematopoiesis. To investigate how leukemic cells inhibit the osteogenic differentiation of BMSCs and the role of...

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Detalles Bibliográficos
Autores principales:	Yang, Gui-Cun, Xu, You-Hua, Chen, Hong-Xia, Wang, Xiao-Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539167/ https://www.ncbi.nlm.nih.gov/pubmed/26339248 http://dx.doi.org/10.1155/2015/162410

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