The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease

Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory...

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Detalles Bibliográficos
Autores principales: Marton, Nikolett, Baricza, Eszter, Érsek, Barbara, Buzás, Edit I., Nagy, György
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539169/
https://www.ncbi.nlm.nih.gov/pubmed/26339145
http://dx.doi.org/10.1155/2015/952536
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author Marton, Nikolett
Baricza, Eszter
Érsek, Barbara
Buzás, Edit I.
Nagy, György
author_facet Marton, Nikolett
Baricza, Eszter
Érsek, Barbara
Buzás, Edit I.
Nagy, György
author_sort Marton, Nikolett
collection PubMed
description Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.
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spelling pubmed-45391692015-09-03 The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease Marton, Nikolett Baricza, Eszter Érsek, Barbara Buzás, Edit I. Nagy, György Mediators Inflamm Review Article Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins. Hindawi Publishing Corporation 2015 2015-08-03 /pmc/articles/PMC4539169/ /pubmed/26339145 http://dx.doi.org/10.1155/2015/952536 Text en Copyright © 2015 Nikolett Marton et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Marton, Nikolett
Baricza, Eszter
Érsek, Barbara
Buzás, Edit I.
Nagy, György
The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease
title The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease
title_full The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease
title_fullStr The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease
title_full_unstemmed The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease
title_short The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease
title_sort emerging and diverse roles of src-like adaptor proteins in health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539169/
https://www.ncbi.nlm.nih.gov/pubmed/26339145
http://dx.doi.org/10.1155/2015/952536
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