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Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments

Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota. Crohn's disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention due to thei...

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Autores principales: de Mattos, Bruno Rafael Ramos, Garcia, Maellin Pereira Gracindo, Nogueira, Julia Bier, Paiatto, Lisiery Negrini, Albuquerque, Cassia Galdino, Souza, Caique Lopes, Fernandes, Luís Gustavo Romani, Tamashiro, Wirla Maria da Silva Cunha, Simioni, Patricia Ucelli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539174/
https://www.ncbi.nlm.nih.gov/pubmed/26339135
http://dx.doi.org/10.1155/2015/493012
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author de Mattos, Bruno Rafael Ramos
Garcia, Maellin Pereira Gracindo
Nogueira, Julia Bier
Paiatto, Lisiery Negrini
Albuquerque, Cassia Galdino
Souza, Caique Lopes
Fernandes, Luís Gustavo Romani
Tamashiro, Wirla Maria da Silva Cunha
Simioni, Patricia Ucelli
author_facet de Mattos, Bruno Rafael Ramos
Garcia, Maellin Pereira Gracindo
Nogueira, Julia Bier
Paiatto, Lisiery Negrini
Albuquerque, Cassia Galdino
Souza, Caique Lopes
Fernandes, Luís Gustavo Romani
Tamashiro, Wirla Maria da Silva Cunha
Simioni, Patricia Ucelli
author_sort de Mattos, Bruno Rafael Ramos
collection PubMed
description Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota. Crohn's disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention due to their increasing incidence. Recent studies have pointed out genes associated with IBD susceptibility that, together with environment factors, may contribute to the outcome of the disease. In ulcerative colitis, there are several therapies available, depending on the stage of the disease. Aminosalicylates, corticosteroids, and cyclosporine are used to treat mild, moderate, and severe disease, respectively. In Crohn's disease, drug choices are dependent on both location and behavior of the disease. Nowadays, advances in treatments for IBD have included biological therapies, based mainly on monoclonal antibodies or fusion proteins, such as anti-TNF drugs. Notwithstanding the high cost involved, these biological therapies show a high index of remission, enabling a significant reduction in cases of surgery and hospitalization. Furthermore, migration inhibitors and new cytokine blockers are also a promising alternative for treating patients with IBD. In this review, an analysis of literature data on biological treatments for IBD is approached, with the main focus on therapies based on emerging recombinant biomolecules.
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spelling pubmed-45391742015-09-03 Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments de Mattos, Bruno Rafael Ramos Garcia, Maellin Pereira Gracindo Nogueira, Julia Bier Paiatto, Lisiery Negrini Albuquerque, Cassia Galdino Souza, Caique Lopes Fernandes, Luís Gustavo Romani Tamashiro, Wirla Maria da Silva Cunha Simioni, Patricia Ucelli Mediators Inflamm Review Article Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota. Crohn's disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention due to their increasing incidence. Recent studies have pointed out genes associated with IBD susceptibility that, together with environment factors, may contribute to the outcome of the disease. In ulcerative colitis, there are several therapies available, depending on the stage of the disease. Aminosalicylates, corticosteroids, and cyclosporine are used to treat mild, moderate, and severe disease, respectively. In Crohn's disease, drug choices are dependent on both location and behavior of the disease. Nowadays, advances in treatments for IBD have included biological therapies, based mainly on monoclonal antibodies or fusion proteins, such as anti-TNF drugs. Notwithstanding the high cost involved, these biological therapies show a high index of remission, enabling a significant reduction in cases of surgery and hospitalization. Furthermore, migration inhibitors and new cytokine blockers are also a promising alternative for treating patients with IBD. In this review, an analysis of literature data on biological treatments for IBD is approached, with the main focus on therapies based on emerging recombinant biomolecules. Hindawi Publishing Corporation 2015 2015-08-03 /pmc/articles/PMC4539174/ /pubmed/26339135 http://dx.doi.org/10.1155/2015/493012 Text en Copyright © 2015 Bruno Rafael Ramos de Mattos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
de Mattos, Bruno Rafael Ramos
Garcia, Maellin Pereira Gracindo
Nogueira, Julia Bier
Paiatto, Lisiery Negrini
Albuquerque, Cassia Galdino
Souza, Caique Lopes
Fernandes, Luís Gustavo Romani
Tamashiro, Wirla Maria da Silva Cunha
Simioni, Patricia Ucelli
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
title Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
title_full Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
title_fullStr Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
title_full_unstemmed Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
title_short Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
title_sort inflammatory bowel disease: an overview of immune mechanisms and biological treatments
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539174/
https://www.ncbi.nlm.nih.gov/pubmed/26339135
http://dx.doi.org/10.1155/2015/493012
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