Optogenetic activation of intracellular adenosine A(2A) receptor signaling in hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer’s disease through the antagonism of adenosine A(2A) receptors (A(2A)R). To test if A(2A)R activation in hippocampus is actually sufficient to impair memory function and to beg...

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Detalles Bibliográficos
Autores principales: Li, Ping, Rial, Daniel, Canas, Paula M., Yoo, Ji-Hoon, Li, Wei, Zhou, Xiangtian, Wang, Yumei, van Westen, Gerard J.P., Payen, Marie-Pierre, Augusto, Elisabete, Gonçalves, Nélio, Tomé, Angelo R., Li, Zhihui, Wu, Zhongnan, Hou, Xianhua, Zhou, Yuanguo, IJzerman, Ad P., Boyden, Edward S., Cunha, Rodrigo A., Qu, Jia, Chen, Jiang-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539301/
https://www.ncbi.nlm.nih.gov/pubmed/25687775
http://dx.doi.org/10.1038/mp.2014.182

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