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Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis

Tumor-induced angiogenesis is the bridge between avascular and vascular tumor growth phases. In tumor-induced angiogenesis, endothelial cells start to migrate and proliferate toward the tumor and build new capillaries toward the tumor. There are two stages for sprout extension during angiogenesis. T...

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Autores principales: Bazmara, Hossein, Soltani, M., Raahemifar, Kaamran, Sefidgar, Mostafa, Bazargan, Majid, Naeenian, Mojtaba Mousavi, Elkamel, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539440/
https://www.ncbi.nlm.nih.gov/pubmed/26346668
http://dx.doi.org/10.1155/2015/908757
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author Bazmara, Hossein
Soltani, M.
Raahemifar, Kaamran
Sefidgar, Mostafa
Bazargan, Majid
Naeenian, Mojtaba Mousavi
Elkamel, Ali
author_facet Bazmara, Hossein
Soltani, M.
Raahemifar, Kaamran
Sefidgar, Mostafa
Bazargan, Majid
Naeenian, Mojtaba Mousavi
Elkamel, Ali
author_sort Bazmara, Hossein
collection PubMed
description Tumor-induced angiogenesis is the bridge between avascular and vascular tumor growth phases. In tumor-induced angiogenesis, endothelial cells start to migrate and proliferate toward the tumor and build new capillaries toward the tumor. There are two stages for sprout extension during angiogenesis. The first stage is prior to anastomosis, when single sprouts extend. The second stage is after anastomosis when closed flow pathways or loops are formed and blood flows in the closed loops. Prior to anastomosis, biochemical and biomechanical signals from extracellular matrix regulate endothelial cell phenotype; however, after anastomosis, blood flow is the main regulator of endothelial cell phenotype. In this study, the critical signaling pathways of each stage are introduced. A Boolean network model is used to map environmental and flow induced signals to endothelial cell phenotype (proliferation, migration, apoptosis, and lumen formation). Using the Boolean network model, blockade of intracellular signaling molecules of endothelial cell is investigated prior to and after anastomosis and the cell fate is obtained in each case. Activation of apoptotic signal in endothelial cell can prevent the extension of new vessels and may inhibit angiogenesis. It is shown that blockade of a few signaling molecules in endothelial cell activates apoptotic signal that are proposed as antiangiogenic strategies.
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spelling pubmed-45394402015-09-06 Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis Bazmara, Hossein Soltani, M. Raahemifar, Kaamran Sefidgar, Mostafa Bazargan, Majid Naeenian, Mojtaba Mousavi Elkamel, Ali Biomed Res Int Research Article Tumor-induced angiogenesis is the bridge between avascular and vascular tumor growth phases. In tumor-induced angiogenesis, endothelial cells start to migrate and proliferate toward the tumor and build new capillaries toward the tumor. There are two stages for sprout extension during angiogenesis. The first stage is prior to anastomosis, when single sprouts extend. The second stage is after anastomosis when closed flow pathways or loops are formed and blood flows in the closed loops. Prior to anastomosis, biochemical and biomechanical signals from extracellular matrix regulate endothelial cell phenotype; however, after anastomosis, blood flow is the main regulator of endothelial cell phenotype. In this study, the critical signaling pathways of each stage are introduced. A Boolean network model is used to map environmental and flow induced signals to endothelial cell phenotype (proliferation, migration, apoptosis, and lumen formation). Using the Boolean network model, blockade of intracellular signaling molecules of endothelial cell is investigated prior to and after anastomosis and the cell fate is obtained in each case. Activation of apoptotic signal in endothelial cell can prevent the extension of new vessels and may inhibit angiogenesis. It is shown that blockade of a few signaling molecules in endothelial cell activates apoptotic signal that are proposed as antiangiogenic strategies. Hindawi Publishing Corporation 2015 2015-08-04 /pmc/articles/PMC4539440/ /pubmed/26346668 http://dx.doi.org/10.1155/2015/908757 Text en Copyright © 2015 Hossein Bazmara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bazmara, Hossein
Soltani, M.
Raahemifar, Kaamran
Sefidgar, Mostafa
Bazargan, Majid
Naeenian, Mojtaba Mousavi
Elkamel, Ali
Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis
title Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis
title_full Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis
title_fullStr Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis
title_full_unstemmed Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis
title_short Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis
title_sort activation of apoptotic signal in endothelial cells through intracellular signaling molecules blockade in tumor-induced angiogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539440/
https://www.ncbi.nlm.nih.gov/pubmed/26346668
http://dx.doi.org/10.1155/2015/908757
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