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Multiscale Modeling Indicates That Temperature Dependent [Ca(2+)](i) Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity

Changes in the cytosolic Ca(2+) concentration ([Ca(2+)](i)) are the most predominant active signaling mechanism in astrocytes that can modulate neuronal activity and is assumed to influence neuronal plasticity. Although Ca(2+) signaling in astrocytes has been intensively studied in the past, our und...

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Detalles Bibliográficos
Autores principales: Komin, Niko, Moein, Mahsa, Ellisman, Mark H., Skupin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539483/
https://www.ncbi.nlm.nih.gov/pubmed/26347125
http://dx.doi.org/10.1155/2015/683490