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Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells
Resistance to targeted cancer therapies is an important clinical problem. The discovery of anti-resistance drug combinations is challenging as resistance can arise by diverse escape mechanisms. To address this challenge, we improved and applied the experimental-computational perturbation biology met...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539601/ https://www.ncbi.nlm.nih.gov/pubmed/26284497 http://dx.doi.org/10.7554/eLife.04640 |