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Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach

Interaction of myeloma cells with osteoclasts (OC) can enhance tumor cell expansion through activation of complex signaling transduction networks. Both cells reside in the bone marrow, a hypoxic niche. How OC-myeloma interaction in a hypoxic environment affects myeloma cell growth and their response...

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Detalles Bibliográficos
Autores principales:	Ji, Zhiwei, Wu, Dan, Zhao, Weiling, Peng, Huiming, Zhao, Shengjie, Huang, Deshuang, Zhou, Xiaobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539608/ https://www.ncbi.nlm.nih.gov/pubmed/26282073 http://dx.doi.org/10.1038/srep13291

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