OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation

Translation is a fundamental cellular process, and its dysregulation can contribute to human diseases such as cancer. During translation initiation the eukaryotic initiation factor 2 (eIF2) forms a ternary complex (TC) with GTP and the initiator methionyl-tRNA (tRNAi), mediating ribosomal recruitmen...

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Detalles Bibliográficos
Autores principales: Chen, Huarong, Song, Renduo, Wang, Guohui, Ding, Zonghui, Yang, Chunying, Zhang, Jiawei, Zeng, Zihua, Rubio, Valentina, Wang, Luchang, Zu, Nancy, Weiskoff, Amanda M., Minze, Laurie J., Jeyabal, Prince V.S., Mansour, Oula C., Bai, Li, Merrick, William C., Zheng, Shu, Shi, Zheng-Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539610/
https://www.ncbi.nlm.nih.gov/pubmed/26283179
http://dx.doi.org/10.1038/srep13241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539610/
https://www.ncbi.nlm.nih.gov/pubmed/26283179
http://dx.doi.org/10.1038/srep13241

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