Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease

BACKGROUND & AIMS: Defects in intestinal innate defense systems predispose patients to inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated by nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases in the mucosal barrier maintain gut homeostasis and defend against path...

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Detalles Bibliográficos
Autores principales: Hayes, Patti, Dhillon, Sandeep, O’Neill, Kim, Thoeni, Cornelia, Hui, Ken Y., Elkadri, Abdul, Guo, Conghui H., Kovacic, Lidija, Aviello, Gabriella, Alvarez, Luis A., Griffiths, Anne M., Snapper, Scott B., Brant, Steven R., Doroshow, James H., Silverberg, Mark S., Peter, Inga, McGovern, Dermot P.B., Cho, Judy, Brumell, John H., Uhlig, Holm H., Bourke, Billy, Muise, Aleixo M., Knaus, Ulla G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539615/
https://www.ncbi.nlm.nih.gov/pubmed/26301257
http://dx.doi.org/10.1016/j.jcmgh.2015.06.005

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