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Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres

BACKGROUND: The STAT3 transcription factor is a major intracellular signaling protein and is frequently dysregulated in the most common and lethal brain malignancy in adults, glioblastoma multiforme (GBM). Activation of STAT3 in GBM correlates with malignancy and poor prognosis. The phosphorylating...

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Detalles Bibliográficos
Autores principales:	Mukthavaram, Rajesh, Ouyang, Xiao, Saklecha, Rohit, Jiang, Pengfei, Nomura, Natsuko, Pingle, Sandeep C, Guo, Fang, Makale, Milan, Kesari, Santosh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539675/ https://www.ncbi.nlm.nih.gov/pubmed/26283544 http://dx.doi.org/10.1186/s12967-015-0627-5

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