α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways

BACKGROUND: Diets rich in the n-3 fatty acid alpha-linolenic acid (ALA) have been shown to reduce breast tumor growth, enhance the effectiveness of the HER2-targeted drug trastuzumab (TRAS) and reduce HER2 signaling in mouse models. It is unclear whether this is due to direct effects of ALA or due t...

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Detalles Bibliográficos
Autores principales: Mason, Julie K., Klaire, Sukhpreet, Kharotia, Shikhil, Wiggins, Ashleigh K A, Thompson, Lilian U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539855/
https://www.ncbi.nlm.nih.gov/pubmed/26282560
http://dx.doi.org/10.1186/s12944-015-0090-6

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