Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?

Mesenchymal stem/stromal cells (MSCs) feature promising potential for cellular therapies, yet significant progress in development of MSC therapeutics and assays is hampered because of remarkable MSC heterogeneity in vivo and in vitro. This heterogeneity poses challenges for standardization of MSC ch...

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Detalles Bibliográficos
Autores principales: Jones, Elena, Schäfer, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539918/
https://www.ncbi.nlm.nih.gov/pubmed/26282627
http://dx.doi.org/10.1186/s13287-015-0144-8
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author Jones, Elena
Schäfer, Richard
author_facet Jones, Elena
Schäfer, Richard
author_sort Jones, Elena
collection PubMed
description Mesenchymal stem/stromal cells (MSCs) feature promising potential for cellular therapies, yet significant progress in development of MSC therapeutics and assays is hampered because of remarkable MSC heterogeneity in vivo and in vitro. This heterogeneity poses challenges for standardization of MSC characterization and potency assays as well as for MSC study comparability and manufacturing. This review discusses promising marker combinations for prospective MSC subpopulation enrichment and expansion, and reflects MSC phenotype changes due to environment and age. In order to address animal modelling in MSC biology, comparison of mouse and human MSC markers highlights current common ground of MSCs between species.
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spelling pubmed-45399182015-08-19 Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species? Jones, Elena Schäfer, Richard Stem Cell Res Ther Review Mesenchymal stem/stromal cells (MSCs) feature promising potential for cellular therapies, yet significant progress in development of MSC therapeutics and assays is hampered because of remarkable MSC heterogeneity in vivo and in vitro. This heterogeneity poses challenges for standardization of MSC characterization and potency assays as well as for MSC study comparability and manufacturing. This review discusses promising marker combinations for prospective MSC subpopulation enrichment and expansion, and reflects MSC phenotype changes due to environment and age. In order to address animal modelling in MSC biology, comparison of mouse and human MSC markers highlights current common ground of MSCs between species. BioMed Central 2015-08-18 /pmc/articles/PMC4539918/ /pubmed/26282627 http://dx.doi.org/10.1186/s13287-015-0144-8 Text en © Jones and Schäfer. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jones, Elena
Schäfer, Richard
Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
title Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
title_full Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
title_fullStr Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
title_full_unstemmed Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
title_short Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
title_sort where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539918/
https://www.ncbi.nlm.nih.gov/pubmed/26282627
http://dx.doi.org/10.1186/s13287-015-0144-8
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