Cargando…
Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study
Introduction. Sleep disturbances are commonly found in patients in the postoperative period. Sleep disturbances may give rise to several complications including cardiopulmonary instability, transient cognitive dysfunction and prolonged convalescence. Many factors including host inflammatory response...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540026/ https://www.ncbi.nlm.nih.gov/pubmed/26290799 http://dx.doi.org/10.7717/peerj.1146 |
_version_ | 1782386184473804800 |
---|---|
author | Huang, Chenxi Alamili, Mahdi Nielsen, Claus Henrik Rosenberg, Jacob Gögenur, Ismail |
author_facet | Huang, Chenxi Alamili, Mahdi Nielsen, Claus Henrik Rosenberg, Jacob Gögenur, Ismail |
author_sort | Huang, Chenxi |
collection | PubMed |
description | Introduction. Sleep disturbances are commonly found in patients in the postoperative period. Sleep disturbances may give rise to several complications including cardiopulmonary instability, transient cognitive dysfunction and prolonged convalescence. Many factors including host inflammatory responses are believed to cause postoperative sleep disturbances, as inflammatory responses can alter sleep architecture through cytokine-brain interactions. Our aim was to investigate alteration of sleep architecture during acute infection and its relationships to inflammation and clinical symptoms. Materials & Methods. In this observational study, we included patients with acute uncomplicated diverticulitis as a model to investigate the isolated effects of inflammatory responses on sleep. Eleven patients completed the study. Patients were admitted and treated with antibiotics for two nights, during which study endpoints were measured by polysomnography recordings, self-reported discomfort scores and blood samples of cytokines. One month later, the patients, who now were in complete remission, were readmitted and the endpoints were re-measured (the baseline values). Results. Total sleep time was reduced 4% and 7% the first (p = 0.006) and second (p = 0.014) nights of diverticulitis, compared to baseline, respectively. The rapid eye movement sleep was reduced 33% the first night (p = 0.016), compared to baseline. Moreover, plasma IL-6 levels were correlated to non-rapid eye movement sleep, rapid eye movement sleep and fatigue. Conclusion. Total sleep time and rapid eye movement sleep were reduced during nights with active diverticulitis and correlated with markers of inflammation. |
format | Online Article Text |
id | pubmed-4540026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45400262015-08-19 Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study Huang, Chenxi Alamili, Mahdi Nielsen, Claus Henrik Rosenberg, Jacob Gögenur, Ismail PeerJ Anaesthesiology and Pain Management Introduction. Sleep disturbances are commonly found in patients in the postoperative period. Sleep disturbances may give rise to several complications including cardiopulmonary instability, transient cognitive dysfunction and prolonged convalescence. Many factors including host inflammatory responses are believed to cause postoperative sleep disturbances, as inflammatory responses can alter sleep architecture through cytokine-brain interactions. Our aim was to investigate alteration of sleep architecture during acute infection and its relationships to inflammation and clinical symptoms. Materials & Methods. In this observational study, we included patients with acute uncomplicated diverticulitis as a model to investigate the isolated effects of inflammatory responses on sleep. Eleven patients completed the study. Patients were admitted and treated with antibiotics for two nights, during which study endpoints were measured by polysomnography recordings, self-reported discomfort scores and blood samples of cytokines. One month later, the patients, who now were in complete remission, were readmitted and the endpoints were re-measured (the baseline values). Results. Total sleep time was reduced 4% and 7% the first (p = 0.006) and second (p = 0.014) nights of diverticulitis, compared to baseline, respectively. The rapid eye movement sleep was reduced 33% the first night (p = 0.016), compared to baseline. Moreover, plasma IL-6 levels were correlated to non-rapid eye movement sleep, rapid eye movement sleep and fatigue. Conclusion. Total sleep time and rapid eye movement sleep were reduced during nights with active diverticulitis and correlated with markers of inflammation. PeerJ Inc. 2015-08-13 /pmc/articles/PMC4540026/ /pubmed/26290799 http://dx.doi.org/10.7717/peerj.1146 Text en © 2015 Huang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Anaesthesiology and Pain Management Huang, Chenxi Alamili, Mahdi Nielsen, Claus Henrik Rosenberg, Jacob Gögenur, Ismail Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study |
title | Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study |
title_full | Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study |
title_fullStr | Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study |
title_full_unstemmed | Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study |
title_short | Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study |
title_sort | rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis—an observational study |
topic | Anaesthesiology and Pain Management |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540026/ https://www.ncbi.nlm.nih.gov/pubmed/26290799 http://dx.doi.org/10.7717/peerj.1146 |
work_keys_str_mv | AT huangchenxi rapideyemovementsleepisreducedinpatientswithacuteuncomplicateddiverticulitisanobservationalstudy AT alamilimahdi rapideyemovementsleepisreducedinpatientswithacuteuncomplicateddiverticulitisanobservationalstudy AT nielsenclaushenrik rapideyemovementsleepisreducedinpatientswithacuteuncomplicateddiverticulitisanobservationalstudy AT rosenbergjacob rapideyemovementsleepisreducedinpatientswithacuteuncomplicateddiverticulitisanobservationalstudy AT gogenurismail rapideyemovementsleepisreducedinpatientswithacuteuncomplicateddiverticulitisanobservationalstudy |