(210)Po microsphere radiological design for tumor vascular disruption

The feasibility of disrupting a tumor’s vascular structure using (210)Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for (210)Po alpha particles are sufficient to disrupt a tumor’s arteriole structure while minimizing the...

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Detalles Bibliográficos
Autor principal: Bevelacqua, JJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540027/
https://www.ncbi.nlm.nih.gov/pubmed/26290796
http://dx.doi.org/10.7717/peerj.1143
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author Bevelacqua, JJ
author_facet Bevelacqua, JJ
author_sort Bevelacqua, JJ
collection PubMed
description The feasibility of disrupting a tumor’s vascular structure using (210)Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for (210)Po alpha particles are sufficient to disrupt a tumor’s arteriole structure while minimizing the dose outside the blood vessel wall. (210)Po photons contribute minimal dose to healthy tissue. The requisite activity of (210)Po to facilitate vascular disruption is calculated.
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spelling pubmed-45400272015-08-19 (210)Po microsphere radiological design for tumor vascular disruption Bevelacqua, JJ PeerJ Biophysics The feasibility of disrupting a tumor’s vascular structure using (210)Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for (210)Po alpha particles are sufficient to disrupt a tumor’s arteriole structure while minimizing the dose outside the blood vessel wall. (210)Po photons contribute minimal dose to healthy tissue. The requisite activity of (210)Po to facilitate vascular disruption is calculated. PeerJ Inc. 2015-08-04 /pmc/articles/PMC4540027/ /pubmed/26290796 http://dx.doi.org/10.7717/peerj.1143 Text en © 2015 Bevelacqua http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biophysics
Bevelacqua, JJ
(210)Po microsphere radiological design for tumor vascular disruption
title (210)Po microsphere radiological design for tumor vascular disruption
title_full (210)Po microsphere radiological design for tumor vascular disruption
title_fullStr (210)Po microsphere radiological design for tumor vascular disruption
title_full_unstemmed (210)Po microsphere radiological design for tumor vascular disruption
title_short (210)Po microsphere radiological design for tumor vascular disruption
title_sort (210)po microsphere radiological design for tumor vascular disruption
topic Biophysics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540027/
https://www.ncbi.nlm.nih.gov/pubmed/26290796
http://dx.doi.org/10.7717/peerj.1143
work_keys_str_mv AT bevelacquajj 210pomicrosphereradiologicaldesignfortumorvasculardisruption

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