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Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates
Polyketide synthase (PKS) β-processing domains are responsible for much of the stereochemical complexity of polyketide natural products. Although the importance of β-processing domains has been well noted and significantly explored, key stereochemical details pertaining to cryptic stereochemistry an...
Autores principales: | Fiers, William D., Dodge, Greg J., Li, Yang, Smith, Janet L., Fecik, Robert A., Aldrich, Courtney C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540058/ https://www.ncbi.nlm.nih.gov/pubmed/26366283 http://dx.doi.org/10.1039/c5sc01505g |
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