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The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin

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Tumour progression and therapy resistance in squamous cell carcinoma of the skin (SCC) is strongly associated with resistance to intrinsic mitochondrial apoptosis. We thus investigated the role of various anti-apoptotic Bcl-2 proteins for apoptosis protection in SCC using the BH3 agonist ABT737 that...

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Detalles Bibliográficos
Autores principales:	Geserick, P, Wang, J, Feoktistova, M, Leverkus, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540197/ https://www.ncbi.nlm.nih.gov/pubmed/25210795 http://dx.doi.org/10.1038/cddis.2014.379

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