Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation

The deregulation of miR-101 and DNMT3a has been implicated in the pathogenesis of multiple tumor types, but whether and how miR-101 silencing and DNMT3a overexpression contribute to lung tumorigenesis remain elusive. Here we show that miR-101 downregulation associates with DNMT3a overexpression in l...

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Detalles Bibliográficos
Autores principales: Yan, F, Shen, N, Pang, J, Xie, D, Deng, B, Molina, J R, Yang, P, Liu, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540207/
https://www.ncbi.nlm.nih.gov/pubmed/25210796
http://dx.doi.org/10.1038/cddis.2014.380

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