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A method using artificial neural networks to morphologically assess mouse blastocyst quality
BACKGROUND: Morphologically classifying embryos is important for numerous laboratory techniques, which range from basic methods to methods for assisted reproduction. However, the standard method currently used for classification is subjective and depends on an embryologist’s prior training. Thus, ou...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540264/ https://www.ncbi.nlm.nih.gov/pubmed/26290704 http://dx.doi.org/10.1186/2055-0391-56-15 |
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author | Matos, Felipe Delestro Rocha, José Celso Nogueira, Marcelo Fábio Gouveia |
author_facet | Matos, Felipe Delestro Rocha, José Celso Nogueira, Marcelo Fábio Gouveia |
author_sort | Matos, Felipe Delestro |
collection | PubMed |
description | BACKGROUND: Morphologically classifying embryos is important for numerous laboratory techniques, which range from basic methods to methods for assisted reproduction. However, the standard method currently used for classification is subjective and depends on an embryologist’s prior training. Thus, our work was aimed at developing software to classify morphological quality for blastocysts based on digital images. METHODS: The developed methodology is suitable for the assistance of the embryologist on the task of analyzing blastocysts. The software uses artificial neural network techniques as a machine learning technique. These networks analyze both visual variables extracted from an image and biological features for an embryo. RESULTS: After the training process the final accuracy of the system using this method was 95%. To aid the end-users in operating this system, we developed a graphical user interface that can be used to produce a quality assessment based on a previously trained artificial neural network. CONCLUSIONS: This process has a high potential for applicability because it can be adapted to additional species with greater economic appeal (human beings and cattle). Based on an objective assessment (without personal bias from the embryologist) and with high reproducibility between samples or different clinics and laboratories, this method will facilitate such classification in the future as an alternative practice for assessing embryo morphologies. |
format | Online Article Text |
id | pubmed-4540264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45402642015-08-19 A method using artificial neural networks to morphologically assess mouse blastocyst quality Matos, Felipe Delestro Rocha, José Celso Nogueira, Marcelo Fábio Gouveia J Anim Sci Technol Research BACKGROUND: Morphologically classifying embryos is important for numerous laboratory techniques, which range from basic methods to methods for assisted reproduction. However, the standard method currently used for classification is subjective and depends on an embryologist’s prior training. Thus, our work was aimed at developing software to classify morphological quality for blastocysts based on digital images. METHODS: The developed methodology is suitable for the assistance of the embryologist on the task of analyzing blastocysts. The software uses artificial neural network techniques as a machine learning technique. These networks analyze both visual variables extracted from an image and biological features for an embryo. RESULTS: After the training process the final accuracy of the system using this method was 95%. To aid the end-users in operating this system, we developed a graphical user interface that can be used to produce a quality assessment based on a previously trained artificial neural network. CONCLUSIONS: This process has a high potential for applicability because it can be adapted to additional species with greater economic appeal (human beings and cattle). Based on an objective assessment (without personal bias from the embryologist) and with high reproducibility between samples or different clinics and laboratories, this method will facilitate such classification in the future as an alternative practice for assessing embryo morphologies. BioMed Central 2014-08-30 /pmc/articles/PMC4540264/ /pubmed/26290704 http://dx.doi.org/10.1186/2055-0391-56-15 Text en © Matos et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Matos, Felipe Delestro Rocha, José Celso Nogueira, Marcelo Fábio Gouveia A method using artificial neural networks to morphologically assess mouse blastocyst quality |
title | A method using artificial neural networks to morphologically assess mouse blastocyst quality |
title_full | A method using artificial neural networks to morphologically assess mouse blastocyst quality |
title_fullStr | A method using artificial neural networks to morphologically assess mouse blastocyst quality |
title_full_unstemmed | A method using artificial neural networks to morphologically assess mouse blastocyst quality |
title_short | A method using artificial neural networks to morphologically assess mouse blastocyst quality |
title_sort | method using artificial neural networks to morphologically assess mouse blastocyst quality |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540264/ https://www.ncbi.nlm.nih.gov/pubmed/26290704 http://dx.doi.org/10.1186/2055-0391-56-15 |
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