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HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

Human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, impacts a multitude of cellular processes, including I-κB kinase (IKK)/NF-κB signaling, DNA damage repair, and mitosis. These activities of Tax have been implicated in the development of adult T-cell leukemia (ATL) in HTLV-...

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Detalles Bibliográficos
Autores principales:	Ho, Yik-Khuan, Zhi, Huijun, Bowlin, Tara, Dorjbal, Batsukh, Philip, Subha, Zahoor, Muhammad Atif, Shih, Hsiu-Ming, Semmes, Oliver John, Schaefer, Brian, Glover, J. N. Mark, Giam, Chou-Zen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540474/ https://www.ncbi.nlm.nih.gov/pubmed/26285145 http://dx.doi.org/10.1371/journal.ppat.1005102

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