Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent

Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include,...

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Autores principales: Quaresma, Maria Victória, Bernardes Filho, Fred, Hezel, Janaína, Peretti, Murilo Calvo, Kac, Bernard Kawa, Azulay-Abulafia, Luna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540507/
https://www.ncbi.nlm.nih.gov/pubmed/26312673
http://dx.doi.org/10.1590/abd1806-4841.20153408
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author Quaresma, Maria Victória
Bernardes Filho, Fred
Hezel, Janaína
Peretti, Murilo Calvo
Kac, Bernard Kawa
Azulay-Abulafia, Luna
author_facet Quaresma, Maria Victória
Bernardes Filho, Fred
Hezel, Janaína
Peretti, Murilo Calvo
Kac, Bernard Kawa
Azulay-Abulafia, Luna
author_sort Quaresma, Maria Victória
collection PubMed
description Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.
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spelling pubmed-45405072015-08-20 Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent Quaresma, Maria Victória Bernardes Filho, Fred Hezel, Janaína Peretti, Murilo Calvo Kac, Bernard Kawa Azulay-Abulafia, Luna An Bras Dermatol Case Report Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone. Sociedade Brasileira de Dermatologia 2015 /pmc/articles/PMC4540507/ /pubmed/26312673 http://dx.doi.org/10.1590/abd1806-4841.20153408 Text en © 2015 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Quaresma, Maria Victória
Bernardes Filho, Fred
Hezel, Janaína
Peretti, Murilo Calvo
Kac, Bernard Kawa
Azulay-Abulafia, Luna
Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_full Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_fullStr Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_full_unstemmed Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_short Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_sort dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540507/
https://www.ncbi.nlm.nih.gov/pubmed/26312673
http://dx.doi.org/10.1590/abd1806-4841.20153408
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