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Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin
Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in ma...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540553/ https://www.ncbi.nlm.nih.gov/pubmed/26312719 http://dx.doi.org/10.1590/abd1806-4841.20153708 |
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author | Ma, Han Chen, Meilan Liu, Junru Li, Ying Li, Juan |
author_facet | Ma, Han Chen, Meilan Liu, Junru Li, Ying Li, Juan |
author_sort | Ma, Han |
collection | PubMed |
description | Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin. |
format | Online Article Text |
id | pubmed-4540553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-45405532015-08-20 Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin Ma, Han Chen, Meilan Liu, Junru Li, Ying Li, Juan An Bras Dermatol Case Report Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin. Sociedade Brasileira de Dermatologia 2015 /pmc/articles/PMC4540553/ /pubmed/26312719 http://dx.doi.org/10.1590/abd1806-4841.20153708 Text en © 2015 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ma, Han Chen, Meilan Liu, Junru Li, Ying Li, Juan Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin |
title | Serious stomatitis and esophagitis: a peculiar mucous reaction induced by
pegylated liposomal doxorubicin |
title_full | Serious stomatitis and esophagitis: a peculiar mucous reaction induced by
pegylated liposomal doxorubicin |
title_fullStr | Serious stomatitis and esophagitis: a peculiar mucous reaction induced by
pegylated liposomal doxorubicin |
title_full_unstemmed | Serious stomatitis and esophagitis: a peculiar mucous reaction induced by
pegylated liposomal doxorubicin |
title_short | Serious stomatitis and esophagitis: a peculiar mucous reaction induced by
pegylated liposomal doxorubicin |
title_sort | serious stomatitis and esophagitis: a peculiar mucous reaction induced by
pegylated liposomal doxorubicin |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540553/ https://www.ncbi.nlm.nih.gov/pubmed/26312719 http://dx.doi.org/10.1590/abd1806-4841.20153708 |
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