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Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different...

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Autores principales: Bottasso Arias, Natalia M., García, Marina, Bondar, Constanza, Guzman, Luciana, Redondo, Agustina, Chopita, Nestor, Córsico, Betina, Chirdo, Fernando G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540995/
https://www.ncbi.nlm.nih.gov/pubmed/26346822
http://dx.doi.org/10.1155/2015/738563
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author Bottasso Arias, Natalia M.
García, Marina
Bondar, Constanza
Guzman, Luciana
Redondo, Agustina
Chopita, Nestor
Córsico, Betina
Chirdo, Fernando G.
author_facet Bottasso Arias, Natalia M.
García, Marina
Bondar, Constanza
Guzman, Luciana
Redondo, Agustina
Chopita, Nestor
Córsico, Betina
Chirdo, Fernando G.
author_sort Bottasso Arias, Natalia M.
collection PubMed
description Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.
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spelling pubmed-45409952015-09-06 Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy Bottasso Arias, Natalia M. García, Marina Bondar, Constanza Guzman, Luciana Redondo, Agustina Chopita, Nestor Córsico, Betina Chirdo, Fernando G. Mediators Inflamm Research Article Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa. Hindawi Publishing Corporation 2015 2015-08-05 /pmc/articles/PMC4540995/ /pubmed/26346822 http://dx.doi.org/10.1155/2015/738563 Text en Copyright © 2015 Natalia M. Bottasso Arias et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bottasso Arias, Natalia M.
García, Marina
Bondar, Constanza
Guzman, Luciana
Redondo, Agustina
Chopita, Nestor
Córsico, Betina
Chirdo, Fernando G.
Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_full Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_fullStr Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_full_unstemmed Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_short Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_sort expression pattern of fatty acid binding proteins in celiac disease enteropathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540995/
https://www.ncbi.nlm.nih.gov/pubmed/26346822
http://dx.doi.org/10.1155/2015/738563
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