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Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

Emerging evidence indicate that the mammalian checkpoint kinase ATM induces transcriptional silencing in cis to DNA double-strand breaks (DSBs) through a poorly understood mechanism. Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes indepe...

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Detalles Bibliográficos
Autores principales:	Manfrini, Nicola, Clerici, Michela, Wery, Maxime, Colombo, Chiara Vittoria, Descrimes, Marc, Morillon, Antonin, d'Adda di Fagagna, Fabrizio, Longhese, Maria Pia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541074/ https://www.ncbi.nlm.nih.gov/pubmed/26231041 http://dx.doi.org/10.7554/eLife.08942

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