The treatment of Parkinson's disease with deep brain stimulation: current issues

Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients’ mobility, activities of daily living, emotional well-being and health-re...

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Detalles Bibliográficos
Autores principales: Moldovan, Alexia-Sabine, Groiss, Stefan Jun, Elben, Saskia, Südmeyer, Martin, Schnitzler, Alfons, Wojtecki, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541217/
https://www.ncbi.nlm.nih.gov/pubmed/26330809
http://dx.doi.org/10.4103/1673-5374.160094
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author Moldovan, Alexia-Sabine
Groiss, Stefan Jun
Elben, Saskia
Südmeyer, Martin
Schnitzler, Alfons
Wojtecki, Lars
author_facet Moldovan, Alexia-Sabine
Groiss, Stefan Jun
Elben, Saskia
Südmeyer, Martin
Schnitzler, Alfons
Wojtecki, Lars
author_sort Moldovan, Alexia-Sabine
collection PubMed
description Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients’ mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation.
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spelling pubmed-45412172015-09-01 The treatment of Parkinson's disease with deep brain stimulation: current issues Moldovan, Alexia-Sabine Groiss, Stefan Jun Elben, Saskia Südmeyer, Martin Schnitzler, Alfons Wojtecki, Lars Neural Regen Res Invited Review Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients’ mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation. Medknow Publications & Media Pvt Ltd 2015-07 /pmc/articles/PMC4541217/ /pubmed/26330809 http://dx.doi.org/10.4103/1673-5374.160094 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Moldovan, Alexia-Sabine
Groiss, Stefan Jun
Elben, Saskia
Südmeyer, Martin
Schnitzler, Alfons
Wojtecki, Lars
The treatment of Parkinson's disease with deep brain stimulation: current issues
title The treatment of Parkinson's disease with deep brain stimulation: current issues
title_full The treatment of Parkinson's disease with deep brain stimulation: current issues
title_fullStr The treatment of Parkinson's disease with deep brain stimulation: current issues
title_full_unstemmed The treatment of Parkinson's disease with deep brain stimulation: current issues
title_short The treatment of Parkinson's disease with deep brain stimulation: current issues
title_sort treatment of parkinson's disease with deep brain stimulation: current issues
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541217/
https://www.ncbi.nlm.nih.gov/pubmed/26330809
http://dx.doi.org/10.4103/1673-5374.160094
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