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Breast Milk and Solid Food Shaping Intestinal Immunity
After birth, the intestinal immune system enters a critical developmental stage, in which tolerogenic and pro-inflammatory cells emerge to contribute to the overall health of the host. The neonatal health is continuously challenged by microbial colonization and food intake, first in the form of brea...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541369/ https://www.ncbi.nlm.nih.gov/pubmed/26347740 http://dx.doi.org/10.3389/fimmu.2015.00415 |
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author | Parigi, Sara M. Eldh, Maria Larssen, Pia Gabrielsson, Susanne Villablanca, Eduardo J. |
author_facet | Parigi, Sara M. Eldh, Maria Larssen, Pia Gabrielsson, Susanne Villablanca, Eduardo J. |
author_sort | Parigi, Sara M. |
collection | PubMed |
description | After birth, the intestinal immune system enters a critical developmental stage, in which tolerogenic and pro-inflammatory cells emerge to contribute to the overall health of the host. The neonatal health is continuously challenged by microbial colonization and food intake, first in the form of breast milk or formula and later in the form of solid food. The microbiota and dietary compounds shape the newborn immune system, which acquires the ability to induce tolerance against innocuous antigens or induce pro-inflammatory immune responses against pathogens. Disruption of these homeostatic mechanisms might lead to undesired immune reactions, such as food allergies and inflammatory bowel disease. Hence, a proper education and maturation of the intestinal immune system is likely important to maintain life-long intestinal homeostasis. In this review, the most recent literature regarding the effects of dietary compounds in the development of the intestinal immune system are discussed. |
format | Online Article Text |
id | pubmed-4541369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45413692015-09-07 Breast Milk and Solid Food Shaping Intestinal Immunity Parigi, Sara M. Eldh, Maria Larssen, Pia Gabrielsson, Susanne Villablanca, Eduardo J. Front Immunol Immunology After birth, the intestinal immune system enters a critical developmental stage, in which tolerogenic and pro-inflammatory cells emerge to contribute to the overall health of the host. The neonatal health is continuously challenged by microbial colonization and food intake, first in the form of breast milk or formula and later in the form of solid food. The microbiota and dietary compounds shape the newborn immune system, which acquires the ability to induce tolerance against innocuous antigens or induce pro-inflammatory immune responses against pathogens. Disruption of these homeostatic mechanisms might lead to undesired immune reactions, such as food allergies and inflammatory bowel disease. Hence, a proper education and maturation of the intestinal immune system is likely important to maintain life-long intestinal homeostasis. In this review, the most recent literature regarding the effects of dietary compounds in the development of the intestinal immune system are discussed. Frontiers Media S.A. 2015-08-19 /pmc/articles/PMC4541369/ /pubmed/26347740 http://dx.doi.org/10.3389/fimmu.2015.00415 Text en Copyright © 2015 Parigi, Eldh, Larssen, Gabrielsson and Villablanca. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Parigi, Sara M. Eldh, Maria Larssen, Pia Gabrielsson, Susanne Villablanca, Eduardo J. Breast Milk and Solid Food Shaping Intestinal Immunity |
title | Breast Milk and Solid Food Shaping Intestinal Immunity |
title_full | Breast Milk and Solid Food Shaping Intestinal Immunity |
title_fullStr | Breast Milk and Solid Food Shaping Intestinal Immunity |
title_full_unstemmed | Breast Milk and Solid Food Shaping Intestinal Immunity |
title_short | Breast Milk and Solid Food Shaping Intestinal Immunity |
title_sort | breast milk and solid food shaping intestinal immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541369/ https://www.ncbi.nlm.nih.gov/pubmed/26347740 http://dx.doi.org/10.3389/fimmu.2015.00415 |
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