Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts

Hypertrophic cardiomyopathy is the most common monogenic disorder in cardiology. Despite important advances in understanding disease pathogenesis, it is not clear how flaws in individual sarcomere components are responsible for the observed phenotype. The aim of this article is to provide a brief in...

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Autores principales: Ntelios, Dimitrios, Tzimagiorgis, Georgios, Efthimiadis, Georgios K., Karvounis, Haralambos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541419/
https://www.ncbi.nlm.nih.gov/pubmed/26347658
http://dx.doi.org/10.3389/fphys.2015.00232
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author Ntelios, Dimitrios
Tzimagiorgis, Georgios
Efthimiadis, Georgios K.
Karvounis, Haralambos
author_facet Ntelios, Dimitrios
Tzimagiorgis, Georgios
Efthimiadis, Georgios K.
Karvounis, Haralambos
author_sort Ntelios, Dimitrios
collection PubMed
description Hypertrophic cardiomyopathy is the most common monogenic disorder in cardiology. Despite important advances in understanding disease pathogenesis, it is not clear how flaws in individual sarcomere components are responsible for the observed phenotype. The aim of this article is to provide a brief interpretative analysis of some currently proposed pathophysiological mechanisms of hypertrophic cardiomyopathy, with a special emphasis on alterations in the cardiac mechanical properties.
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spelling pubmed-45414192015-09-07 Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts Ntelios, Dimitrios Tzimagiorgis, Georgios Efthimiadis, Georgios K. Karvounis, Haralambos Front Physiol Physiology Hypertrophic cardiomyopathy is the most common monogenic disorder in cardiology. Despite important advances in understanding disease pathogenesis, it is not clear how flaws in individual sarcomere components are responsible for the observed phenotype. The aim of this article is to provide a brief interpretative analysis of some currently proposed pathophysiological mechanisms of hypertrophic cardiomyopathy, with a special emphasis on alterations in the cardiac mechanical properties. Frontiers Media S.A. 2015-08-19 /pmc/articles/PMC4541419/ /pubmed/26347658 http://dx.doi.org/10.3389/fphys.2015.00232 Text en Copyright © 2015 Ntelios, Tzimagiorgis, Efthimiadis and Karvounis. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ntelios, Dimitrios
Tzimagiorgis, Georgios
Efthimiadis, Georgios K.
Karvounis, Haralambos
Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts
title Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts
title_full Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts
title_fullStr Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts
title_full_unstemmed Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts
title_short Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts
title_sort mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541419/
https://www.ncbi.nlm.nih.gov/pubmed/26347658
http://dx.doi.org/10.3389/fphys.2015.00232
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