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The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1)

Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum PTH concentrations and hypercalciuria. Negative allosteric CaSR modulators, known as calcilytics,...

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Detalles Bibliográficos
Autores principales:	Hannan, Fadil M., Walls, Gerard V., Babinsky, Valerie N., Nesbit, M. Andrew, Kallay, Enikö, Hough, Tertius A., Fraser, William D., Cox, Roger D., Hu, Jianxin, Spiegel, Allen M., Thakker, Rajesh V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541614/ https://www.ncbi.nlm.nih.gov/pubmed/26052899 http://dx.doi.org/10.1210/en.2015-1269

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