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Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial

PURPOSE: Primary vascular dysregulation (PVD) is a condition in which the response to cold temperature or external stimuli is abnormal. We investigated whether triflusal use results in amelioration of PVD symptoms and improvement of several related parameters compared with aspirin. MATERIALS AND MET...

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Autores principales: Shin, Sanghoon, Kim, Kwang-Joon, Cho, In-Jeong, Hong, Geu-Ru, Jang, Yangsoo, Chung, Namsik, Rah, Young Min, Chang, Hyuk-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541651/
https://www.ncbi.nlm.nih.gov/pubmed/26256964
http://dx.doi.org/10.3349/ymj.2015.56.5.1227
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author Shin, Sanghoon
Kim, Kwang-Joon
Cho, In-Jeong
Hong, Geu-Ru
Jang, Yangsoo
Chung, Namsik
Rah, Young Min
Chang, Hyuk-Jae
author_facet Shin, Sanghoon
Kim, Kwang-Joon
Cho, In-Jeong
Hong, Geu-Ru
Jang, Yangsoo
Chung, Namsik
Rah, Young Min
Chang, Hyuk-Jae
author_sort Shin, Sanghoon
collection PubMed
description PURPOSE: Primary vascular dysregulation (PVD) is a condition in which the response to cold temperature or external stimuli is abnormal. We investigated whether triflusal use results in amelioration of PVD symptoms and improvement of several related parameters compared with aspirin. MATERIALS AND METHODS: Eighty-eight PVD patients (54% female, 56±8 years) were randomly selected to receive either triflusal (300 mg, b.i.d.) or aspirin (150 mg, b.i.d.) for a period of 6 weeks followed by crossover. PVD was defined as both red-blood-cell standstill in video-assisted microscopic capillaroscopy during cold stimulation using carbon dioxide gas and a score of more than 7 points in a validated questionnaire. Efficacy of treatment was assessed by 1) cold intolerance symptom severity (CISS) score, 2) finger Doppler indices, and 3) indocyanine green perfusion imaging. RESULTS: The use of triflusal resulted in a greater improvement in CISS score (44.5±18.4 vs. 51.9±16.2; p<0.001) and in mean radial peak systolic velocity (69.8±17.2 vs. 66.1±16.4; p=0.011) compared to aspirin. Furthermore, significant differences were also observed in perfusion rates on indocyanine green perfusion imaging between triflusal and aspirin (45.6±25.8 vs. 51.6±26.9; p=0.020). CONCLUSION: Triflusal was more effective and demonstrated a more consistent impact on the improvement of symptoms and blood flow in patients with PVD than aspirin.
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spelling pubmed-45416512015-09-01 Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial Shin, Sanghoon Kim, Kwang-Joon Cho, In-Jeong Hong, Geu-Ru Jang, Yangsoo Chung, Namsik Rah, Young Min Chang, Hyuk-Jae Yonsei Med J Original Article PURPOSE: Primary vascular dysregulation (PVD) is a condition in which the response to cold temperature or external stimuli is abnormal. We investigated whether triflusal use results in amelioration of PVD symptoms and improvement of several related parameters compared with aspirin. MATERIALS AND METHODS: Eighty-eight PVD patients (54% female, 56±8 years) were randomly selected to receive either triflusal (300 mg, b.i.d.) or aspirin (150 mg, b.i.d.) for a period of 6 weeks followed by crossover. PVD was defined as both red-blood-cell standstill in video-assisted microscopic capillaroscopy during cold stimulation using carbon dioxide gas and a score of more than 7 points in a validated questionnaire. Efficacy of treatment was assessed by 1) cold intolerance symptom severity (CISS) score, 2) finger Doppler indices, and 3) indocyanine green perfusion imaging. RESULTS: The use of triflusal resulted in a greater improvement in CISS score (44.5±18.4 vs. 51.9±16.2; p<0.001) and in mean radial peak systolic velocity (69.8±17.2 vs. 66.1±16.4; p=0.011) compared to aspirin. Furthermore, significant differences were also observed in perfusion rates on indocyanine green perfusion imaging between triflusal and aspirin (45.6±25.8 vs. 51.6±26.9; p=0.020). CONCLUSION: Triflusal was more effective and demonstrated a more consistent impact on the improvement of symptoms and blood flow in patients with PVD than aspirin. Yonsei University College of Medicine 2015-09-01 2015-07-29 /pmc/articles/PMC4541651/ /pubmed/26256964 http://dx.doi.org/10.3349/ymj.2015.56.5.1227 Text en © Copyright: Yonsei University College of Medicine 2015 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shin, Sanghoon
Kim, Kwang-Joon
Cho, In-Jeong
Hong, Geu-Ru
Jang, Yangsoo
Chung, Namsik
Rah, Young Min
Chang, Hyuk-Jae
Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
title Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
title_full Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
title_fullStr Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
title_full_unstemmed Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
title_short Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
title_sort effect of triflusal on primary vascular dysregulation compared with aspirin: a double-blind, randomized, crossover trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541651/
https://www.ncbi.nlm.nih.gov/pubmed/26256964
http://dx.doi.org/10.3349/ymj.2015.56.5.1227
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