Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs

Mycoplasmas may colonize tumor tissue in patients. The cytostatic activity of gemcitabine was dramatically decreased in Mycoplasma hyorhinis-infected tumor cell cultures compared with non-infected tumor cell cultures. This mycoplasma-driven drug deamination could be prevented by exogenous administra...

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Detalles Bibliográficos
Autores principales: Vande Voorde, Johan, Vervaeke, Peter, Liekens, Sandra, Balzarini, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541722/
https://www.ncbi.nlm.nih.gov/pubmed/26322268
http://dx.doi.org/10.1016/j.fob.2015.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541722/
https://www.ncbi.nlm.nih.gov/pubmed/26322268
http://dx.doi.org/10.1016/j.fob.2015.07.007

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