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Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis

BACKGROUND: The FinnishIPF registry is a prospective, longitudinal national registry study on the epidemiology of idiopathic pulmonary fibrosis (IPF). It was designed to describe the characteristics, management and prognosis of prevalent and incident IPF patients. The study was initiated in 2012. ME...

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Autores principales: Kaunisto, Jaana, Kelloniemi, K., Sutinen, E., Hodgson, U., Piilonen, A., Kaarteenaho, R., Mäkitaro, R., Purokivi, M., Lappi-Blanco, E., Saarelainen, S., Kankaanranta, H., Mursu, A., Kanervisto, M., Salomaa, E-R., Myllärniemi, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541726/
https://www.ncbi.nlm.nih.gov/pubmed/26285574
http://dx.doi.org/10.1186/s12890-015-0074-3
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author Kaunisto, Jaana
Kelloniemi, K.
Sutinen, E.
Hodgson, U.
Piilonen, A.
Kaarteenaho, R.
Mäkitaro, R.
Purokivi, M.
Lappi-Blanco, E.
Saarelainen, S.
Kankaanranta, H.
Mursu, A.
Kanervisto, M.
Salomaa, E-R.
Myllärniemi, M.
author_facet Kaunisto, Jaana
Kelloniemi, K.
Sutinen, E.
Hodgson, U.
Piilonen, A.
Kaarteenaho, R.
Mäkitaro, R.
Purokivi, M.
Lappi-Blanco, E.
Saarelainen, S.
Kankaanranta, H.
Mursu, A.
Kanervisto, M.
Salomaa, E-R.
Myllärniemi, M.
author_sort Kaunisto, Jaana
collection PubMed
description BACKGROUND: The FinnishIPF registry is a prospective, longitudinal national registry study on the epidemiology of idiopathic pulmonary fibrosis (IPF). It was designed to describe the characteristics, management and prognosis of prevalent and incident IPF patients. The study was initiated in 2012. METHODS: We present here results limited to five university hospitals. Patients with IPF were screened from hospital registries using ICD-10 diagnosis codes J84.1 and J84.9. All patients who gave informed consent were included and evaluated using novel diagnostic criteria. Point prevalence on the 31(st) of December in 2012 was calculated using the reported population in each university hospital city as the denominator. RESULTS: Patients with ICD-10 codes J84.1 and J84.9 yielded a heterogeneous group – on the basis of patient records assessed by pulmonologists only 20–30 % of the cases were IPF. After clinical, radiological and histological re-evaluation 111 of 123 (90 %) of patients fulfilled the clinical criteria of IPF. The estimated prevalence of IPF was 8.6 cases/100 000. 60.4 % were men. Forty four percent of the patients were never-smokers. At diagnosis, the patients’ mean age was 73.5 years and mean FVC was 80.4 % and DLCO 57.3 % of predicted. CONCLUSIONS: Our results suggest that hospital registries are inaccurate for epidemiological studies unless patients are carefully re-evaluated. IPF is diagnosed in Finland at a stage when lung function is still quite well preserved. Smoking in patients with IPF was less common than in previous reports.
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spelling pubmed-45417262015-08-21 Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis Kaunisto, Jaana Kelloniemi, K. Sutinen, E. Hodgson, U. Piilonen, A. Kaarteenaho, R. Mäkitaro, R. Purokivi, M. Lappi-Blanco, E. Saarelainen, S. Kankaanranta, H. Mursu, A. Kanervisto, M. Salomaa, E-R. Myllärniemi, M. BMC Pulm Med Research Article BACKGROUND: The FinnishIPF registry is a prospective, longitudinal national registry study on the epidemiology of idiopathic pulmonary fibrosis (IPF). It was designed to describe the characteristics, management and prognosis of prevalent and incident IPF patients. The study was initiated in 2012. METHODS: We present here results limited to five university hospitals. Patients with IPF were screened from hospital registries using ICD-10 diagnosis codes J84.1 and J84.9. All patients who gave informed consent were included and evaluated using novel diagnostic criteria. Point prevalence on the 31(st) of December in 2012 was calculated using the reported population in each university hospital city as the denominator. RESULTS: Patients with ICD-10 codes J84.1 and J84.9 yielded a heterogeneous group – on the basis of patient records assessed by pulmonologists only 20–30 % of the cases were IPF. After clinical, radiological and histological re-evaluation 111 of 123 (90 %) of patients fulfilled the clinical criteria of IPF. The estimated prevalence of IPF was 8.6 cases/100 000. 60.4 % were men. Forty four percent of the patients were never-smokers. At diagnosis, the patients’ mean age was 73.5 years and mean FVC was 80.4 % and DLCO 57.3 % of predicted. CONCLUSIONS: Our results suggest that hospital registries are inaccurate for epidemiological studies unless patients are carefully re-evaluated. IPF is diagnosed in Finland at a stage when lung function is still quite well preserved. Smoking in patients with IPF was less common than in previous reports. BioMed Central 2015-08-19 /pmc/articles/PMC4541726/ /pubmed/26285574 http://dx.doi.org/10.1186/s12890-015-0074-3 Text en © Kaunisto et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kaunisto, Jaana
Kelloniemi, K.
Sutinen, E.
Hodgson, U.
Piilonen, A.
Kaarteenaho, R.
Mäkitaro, R.
Purokivi, M.
Lappi-Blanco, E.
Saarelainen, S.
Kankaanranta, H.
Mursu, A.
Kanervisto, M.
Salomaa, E-R.
Myllärniemi, M.
Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
title Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
title_full Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
title_fullStr Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
title_full_unstemmed Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
title_short Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
title_sort re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541726/
https://www.ncbi.nlm.nih.gov/pubmed/26285574
http://dx.doi.org/10.1186/s12890-015-0074-3
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