Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion

OBJECTIVE: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs. METHODS: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 6...

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Detalles Bibliográficos
Autores principales: Dorsa, Rafael Cantero, Pontes, José Carlos Dorsa Vieira, Antoniolli, Andréia Conceição Brochado, da Silva, Guilherme Viotto Rodrigues, Benfatti, Ricardo Adala, dos Santos, Carlos Henrique Marques, Pontes, Elenir Rose Cury, Goldiano, José Anderson Souza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cirurgia Cardiovascular 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541782/
https://www.ncbi.nlm.nih.gov/pubmed/26313726
http://dx.doi.org/10.5935/1678-9741.20150005
Descripción
Sumario:OBJECTIVE: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs. METHODS: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury. RESULTS: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05). CONCLUSION: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

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