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Neurotranscriptome profiles of multiple zebrafish strains

Behavioral displays or physiological responses are often influenced by intrinsic and extrinsic mechanisms in the context of the organism's evolutionary history. Understanding differences in transcriptome profiles can give insight into adaptive or pathological responses. We utilize high throughp...

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Detalles Bibliográficos
Autores principales: Wong, Ryan Y., Godwin, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542015/
https://www.ncbi.nlm.nih.gov/pubmed/26309813
http://dx.doi.org/10.1016/j.gdata.2015.06.004
Descripción
Sumario:Behavioral displays or physiological responses are often influenced by intrinsic and extrinsic mechanisms in the context of the organism's evolutionary history. Understanding differences in transcriptome profiles can give insight into adaptive or pathological responses. We utilize high throughput sequencing (RNA-sequencing) to characterize the neurotranscriptome profiles in both males and females across four strains of zebrafish (Danio rerio). Strains varied by previously documented differences in stress and anxiety-like behavioral responses, and generations removed from wild-caught individuals. Here we describe detailed methodologies and quality controls in generating the raw RNA-sequencing reads that are publically available in NCBI's Gene Expression Omnibus database (GSE61108).