Cargando…

A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember' a previous encounter with a pathogen has not been establis...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramirez, Jose Luis, de Almeida Oliveira, Giselle, Calvo, Eric, Dalli, Jesmond, Colas, Romain A., Serhan, Charles N., Ribeiro, Jose M., Barillas-Mury, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542143/
https://www.ncbi.nlm.nih.gov/pubmed/26100162
http://dx.doi.org/10.1038/ncomms8403
Descripción
Sumario:Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember' a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A(4). Plasmodium ookinete midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/lipocalin complex.