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New Insight into Filamentous Hemagglutinin Secretion Reveals a Role for Full-Length FhaB in Bordetella Virulence

Bordetella filamentous hemagglutinin (FHA), a primary component of acellular pertussis vaccines, contributes to virulence, but how it functions mechanistically is unclear. FHA is first synthesized as an ~370-kDa preproprotein called FhaB. Removal of an N-terminal signal peptide and a large C-termina...

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Detalles Bibliográficos
Autores principales:	Melvin, Jeffrey A., Scheller, Erich V., Noël, Christopher R., Cotter, Peggy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542190/ https://www.ncbi.nlm.nih.gov/pubmed/26286694 http://dx.doi.org/10.1128/mBio.01189-15

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