The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth

The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites. Drosophila Arfaptin is a membrane-binding protein localized to the GA that is required for the growth of the presynaptic nerve term...

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Detalles Bibliográficos
Autores principales: Chang, Leo, Kreko-Pierce, Tabita, Eaton, Benjamin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542281/
https://www.ncbi.nlm.nih.gov/pubmed/26116655
http://dx.doi.org/10.1242/bio.011262
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author Chang, Leo
Kreko-Pierce, Tabita
Eaton, Benjamin A.
author_facet Chang, Leo
Kreko-Pierce, Tabita
Eaton, Benjamin A.
author_sort Chang, Leo
collection PubMed
description The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites. Drosophila Arfaptin is a membrane-binding protein localized to the GA that is required for the growth of the presynaptic nerve terminal. Here we provide biochemical, cellular and genetic evidence that the small GTPase Arl1 and the guanine-nucleotide exchange factor (GEF) Gartenzwerg are required for Arfaptin function at the Golgi during synapse growth. Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology.
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spelling pubmed-45422812015-09-16 The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth Chang, Leo Kreko-Pierce, Tabita Eaton, Benjamin A. Biol Open Research Article The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites. Drosophila Arfaptin is a membrane-binding protein localized to the GA that is required for the growth of the presynaptic nerve terminal. Here we provide biochemical, cellular and genetic evidence that the small GTPase Arl1 and the guanine-nucleotide exchange factor (GEF) Gartenzwerg are required for Arfaptin function at the Golgi during synapse growth. Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology. The Company of Biologists 2015-06-26 /pmc/articles/PMC4542281/ /pubmed/26116655 http://dx.doi.org/10.1242/bio.011262 Text en © 2015. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Chang, Leo
Kreko-Pierce, Tabita
Eaton, Benjamin A.
The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
title The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
title_full The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
title_fullStr The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
title_full_unstemmed The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
title_short The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
title_sort guanine exchange factor gartenzwerg and the small gtpase arl1 function in the same pathway with arfaptin during synapse growth
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542281/
https://www.ncbi.nlm.nih.gov/pubmed/26116655
http://dx.doi.org/10.1242/bio.011262
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