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Cdk1 Restrains NHEJ through Phosphorylation of XRCC4-like Factor Xlf1

Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle. Cyclin-dependent kinase 1 (Cdk1) activates HR by phosphorylation of...

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Detalles Bibliográficos
Autores principales:	Hentges, Pierre, Waller, Helen, Reis, Clara C., Ferreira, Miguel Godinho, Doherty, Aidan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542292/ https://www.ncbi.nlm.nih.gov/pubmed/25533340 http://dx.doi.org/10.1016/j.celrep.2014.11.044

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