Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

Increasing evidence suggests that loss of β cell characteristics may cause insulin secretory deficiency in diabetes, but the underlying mechanisms remain unclear. Here, we show that Rfx6, whose mutation leads to neonatal diabetes in humans, is essential to maintain key features of functionally matur...

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Detalles Bibliográficos
Autores principales: Piccand, Julie, Strasser, Perrine, Hodson, David J., Meunier, Aline, Ye, Tao, Keime, Céline, Birling, Marie-Christine, Rutter, Guy A., Gradwohl, Gérard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542305/
https://www.ncbi.nlm.nih.gov/pubmed/25497096
http://dx.doi.org/10.1016/j.celrep.2014.11.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542305/
https://www.ncbi.nlm.nih.gov/pubmed/25497096
http://dx.doi.org/10.1016/j.celrep.2014.11.033

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