Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation

Fertilization triggers global erasure of paternal 5-methylcytosine as part of epigenetic reprogramming during the transition from gametic specialization to totipotency. This involves oxidation by TET3, but our understanding of its targets and the wider context of demethylation is limited to a small...

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Detalles Bibliográficos
Autores principales: Peat, Julian R., Dean, Wendy, Clark, Stephen J., Krueger, Felix, Smallwood, Sébastien A., Ficz, Gabriella, Kim, Jong Kyoung, Marioni, John C., Hore, Timothy A., Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542306/
https://www.ncbi.nlm.nih.gov/pubmed/25497087
http://dx.doi.org/10.1016/j.celrep.2014.11.034

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