Cargando…

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation

Allogeneic hematopoietic stem cell transplantation (HSCT) can treat certain hematologic malignancies due to the graft versus leukemia (GvL) effect but is complicated by graft versus host disease (GvHD). Expression of the p110δ catalytic subunit of the phosphoinositide 3-kinase pathway is restricted...

Descripción completa

Detalles Bibliográficos
Autores principales:	Doisne, Jean-Marc, Hüber, Christian M., Okkenhaug, Klaus, Colucci, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542309/ https://www.ncbi.nlm.nih.gov/pubmed/25660021 http://dx.doi.org/10.1016/j.celrep.2015.01.002

Ejemplares similares

IL‐12/15/18‐preactivated NK cells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation
por: Hüber, Christian M., et al.
Publicado: (2015)

Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer
por: Ali, Khaled, et al.
Publicado: (2014)

The PI3K p110δ Regulates Expression of CD38 on Regulatory T Cells
por: Patton, Daniel T., et al.
Publicado: (2011)

Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
por: Okkenhaug, Klaus, et al.
Publicado: (2007)

Disrupted PI3K p110δ Signaling Dysregulates Maternal Immune Cells and Increases Fetal Mortality In Mice
por: Kieckbusch, Jens, et al.
Publicado: (2015)

PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4(+) T Cells
por: Luff, Daisy H., et al.
Publicado: (2021)

Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase P110δ Prevents Chronic Rejection of Heart Allografts
por: Ying, Huijun, et al.
Publicado: (2012)

PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1
por: Garçon, Fabien, et al.
Publicado: (2016)

Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophages
por: Goulielmaki, Evangelia, et al.
Publicado: (2018)

PI3K p110δ Is Expressed by gp38(−)CD31(+) and gp38(+)CD31(+) Spleen Stromal Cells and Regulates Their CCL19, CCL21, and LTβR mRNA Levels
por: Zotes, Teresa M., et al.
Publicado: (2013)

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4(+) T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals
por: Mauro, Claudio, et al.
Publicado: (2017)

Phosphatidylinositol 3-kinase p110δ expression in Merkel cell carcinoma
por: Chteinberg, Emil, et al.
Publicado: (2018)

PI3Kδ Regulates the Magnitude of CD8(+) T Cell Responses after Challenge with Listeria monocytogenes
por: Pearce, Verity Q., et al.
Publicado: (2015)

Are cultured mesenchymal stromal cells an option for immunomodulation in transplantation?
por: Plock, Jan A., et al.
Publicado: (2013)

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation
por: Chiu, Honyin, et al.
Publicado: (2017)

Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure
por: Jia, Wenqing, et al.
Publicado: (2022)

On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation
por: Engela, Anja U., et al.
Publicado: (2012)

Clinical results of an inactivated anti-brucella vaccine in combination with immunomodulators
por: Bouchemla, Fayssal, et al.
Publicado: (2020)

The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors
por: Berndt, Alex, et al.
Publicado: (2010)

Regulation of p110δ PI 3-Kinase Gene Expression
por: Kok, Klaartje, et al.
Publicado: (2009)

Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production
por: Barbera Betancourt, Ariana, et al.
Publicado: (2016)

NKG2A Immune Checkpoint in Vδ2 T Cells: Emerging Application in Cancer Immunotherapy
por: Cazzetta, Valentina, et al.
Publicado: (2023)

110 DB analogue ratio (Δ /Σ) processor for closed orbit measurements
por: Christiansen, C
Publicado: (1988)

p110δ PI3 kinase pathway: emerging roles in cancer
por: Tzenaki, Niki, et al.
Publicado: (2013)

Inactivated Platelet Lysate Supports the Proliferation and Immunomodulant Characteristics of Mesenchymal Stromal Cells in GMP Culture Conditions
por: Mareschi, Katia, et al.
Publicado: (2020)

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
por: Clayton, Elizabeth, et al.
Publicado: (2002)

PPARδ status and mismatch repair mediated neoplasia in the mouse intestine
por: Reed, Karen R, et al.
Publicado: (2006)

Molecular definition of group 1 innate lymphoid cells in the mouse uterus
por: Filipovic, Iva, et al.
Publicado: (2018)

Mismatched anti-predator behavioral responses in predator-naïve larval anurans
por: Albecker, Molly, et al.
Publicado: (2015)

Δ40p53 is involved in the inactivation of autophagy and contributes to inhibition of cell death in HCT116-Δ40p53 cells
por: Zang, Yunjin, et al.
Publicado: (2017)

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis
por: Tricarico, Rossella, et al.
Publicado: (2015)

Editorial: Lipid Signaling in T Cell Development and Function
por: Sauer, Karsten, et al.
Publicado: (2015)

Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury
por: Bilancio, Antonio, et al.
Publicado: (2017)

Immunomodulation in Cutaneous T Cell Lymphoma
por: Ferranti, Martina, et al.
Publicado: (2019)

Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ
por: Hassenrück, Floyd, et al.
Publicado: (2023)

Deletion of P110δ promotes the development of myocarditis in ApoE-deficient mice by increasing mononuclear cell peritoneal infiltration
por: Zhang, Qi-Zhi, et al.
Publicado: (2020)

Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase
por: Eickholt, Britta J., et al.
Publicado: (2007)

2660. Infection Complications Following Mismatched Allogeneic Hematopoietic Cell Transplantation
por: Ebisu, Yosuke, et al.
Publicado: (2019)

Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation
por: Zeng, Wenjie, et al.
Publicado: (2019)

The immunomodulation role of Th17 and Treg in renal transplantation
por: Huang, Dan-Lei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mb6kkk6hfkal3jq2nkv63io6v5