Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

Transcription factor fusion proteins can transform cells by inducing global changes of the transcriptome, often creating a state of oncogene addiction. Here, we investigate the role of epigenetic mechanisms in this process, focusing on Ewing sarcoma cells that are dependent on the EWS-FLI1 fusion pr...

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Detalles Bibliográficos
Autores principales: Tomazou, Eleni M., Sheffield, Nathan C., Schmidl, Christian, Schuster, Michael, Schönegger, Andreas, Datlinger, Paul, Kubicek, Stefan, Bock, Christoph, Kovar, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542316/
https://www.ncbi.nlm.nih.gov/pubmed/25704812
http://dx.doi.org/10.1016/j.celrep.2015.01.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542316/
https://www.ncbi.nlm.nih.gov/pubmed/25704812
http://dx.doi.org/10.1016/j.celrep.2015.01.042

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