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Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity

Much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. Chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and antifungal agents etc. The presence of reactive α,β...

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Detalles Bibliográficos
Autores principales: Gupta, Deepa, Jain, D. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542397/
https://www.ncbi.nlm.nih.gov/pubmed/26317075
http://dx.doi.org/10.4103/2231-4040.161507
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author Gupta, Deepa
Jain, D. K.
author_facet Gupta, Deepa
Jain, D. K.
author_sort Gupta, Deepa
collection PubMed
description Much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. Chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and antifungal agents etc. The presence of reactive α,β-unsaturated keto group in chalcones is found to be responsible for their biological activity. The rapid developments of resistance to antifungal agents, led to design, and synthesize the new antifungal agents. The derivatives of chalcones were prepared using Claisen–Schmidt condensation scheme with appropriate tetralone and aldehyde derivatives. Ten derivatives were synthesized and were biologically screened for antifungal activity. The newly synthesized derivatives of chalcone showed antifungal activity against fungal species, Microsporum gypseum. The results so obtained were superior or comparable to ketoconazole. It was observed that none of the compounds tested showed positive results for fungi Candida albicans nor against fungi Aspergillus niger. Chalcone derivatives showed inhibitory effect against M. gypseum species of fungus. It was found that among the chalcone derivatives so synthesized, two of them, that is, 4-chloro derivative, and unsubstituted derivative of chalcone showed antifungal activity superior to ketoconazole. Thus, these can be the potential new molecule as antifungal agent.
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spelling pubmed-45423972015-08-27 Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity Gupta, Deepa Jain, D. K. J Adv Pharm Technol Res Original Article Much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. Chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and antifungal agents etc. The presence of reactive α,β-unsaturated keto group in chalcones is found to be responsible for their biological activity. The rapid developments of resistance to antifungal agents, led to design, and synthesize the new antifungal agents. The derivatives of chalcones were prepared using Claisen–Schmidt condensation scheme with appropriate tetralone and aldehyde derivatives. Ten derivatives were synthesized and were biologically screened for antifungal activity. The newly synthesized derivatives of chalcone showed antifungal activity against fungal species, Microsporum gypseum. The results so obtained were superior or comparable to ketoconazole. It was observed that none of the compounds tested showed positive results for fungi Candida albicans nor against fungi Aspergillus niger. Chalcone derivatives showed inhibitory effect against M. gypseum species of fungus. It was found that among the chalcone derivatives so synthesized, two of them, that is, 4-chloro derivative, and unsubstituted derivative of chalcone showed antifungal activity superior to ketoconazole. Thus, these can be the potential new molecule as antifungal agent. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4542397/ /pubmed/26317075 http://dx.doi.org/10.4103/2231-4040.161507 Text en Copyright: © 2015 Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gupta, Deepa
Jain, D. K.
Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
title Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
title_full Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
title_fullStr Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
title_full_unstemmed Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
title_short Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
title_sort chalcone derivatives as potential antifungal agents: synthesis, and antifungal activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542397/
https://www.ncbi.nlm.nih.gov/pubmed/26317075
http://dx.doi.org/10.4103/2231-4040.161507
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