Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel

Diffuse congenital hyperinsulinism in infancy (CHI-D) arises from mutations inactivating the K(ATP) channel; however, the phenotype is difficult to explain from electrophysiology alone. Here we studied wider abnormalities in the β-cell and other pancreatic lineages. Islets were disorganized in CHI-D...

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Detalles Bibliográficos
Autores principales: Salisbury, Rachel J., Han, Bing, Jennings, Rachel E., Berry, Andrew A., Stevens, Adam, Mohamed, Zainab, Sugden, Sarah A., De Krijger, Ronald, Cross, Sarah E., Johnson, Paul P.V., Newbould, Melanie, Cosgrove, Karen E., Hanley, Karen Piper, Banerjee, Indraneel, Dunne, Mark J., Hanley, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542438/
https://www.ncbi.nlm.nih.gov/pubmed/25931474
http://dx.doi.org/10.2337/db14-1202

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