Click chemistry oligomerisation of azido-alkyne-functionalised galactose accesses triazole-linked linear oligomers and macrocycles that inhibit Trypanosoma cruzi macrophage invasion

Reaction of 2-(2-(2-azidoethoxy)ethoxy)ethyl 6-O-(prop-2-ynyl)-β-d-galactopyranoside (7) under CuAAC conditions gives rise to mixed cyclic and linear triazole-linked oligomers, with individual compounds up to d.p. 5 isolable, along with mixed larger oligomers. The linear compounds resolve en bloc fr...

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Detalles Bibliográficos
Autores principales: Campo, Vanessa L., Ivanova, Irina M., Carvalho, Ivone, Lopes, Carla D., Carneiro, Zumira A., Saalbach, Gerhard, Schenkman, Sergio, da Silva, João Santana, Nepogodiev, Sergey A., Field, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542550/
https://www.ncbi.nlm.nih.gov/pubmed/26435551
http://dx.doi.org/10.1016/j.tet.2015.04.085

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