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The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids

Nowadays, healthcare systems are challenged by a major worldwide drug resistance crisis caused by the massive and rapid dissemination of antibiotic resistance genes and associated emergence of multidrug resistant pathogenic bacteria, in both clinical and environmental settings. Conjugation is the ma...

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Autores principales: Poulin-Laprade, Dominic, Carraro, Nicolas, Burrus, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542580/
https://www.ncbi.nlm.nih.gov/pubmed/26347724
http://dx.doi.org/10.3389/fmicb.2015.00837
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author Poulin-Laprade, Dominic
Carraro, Nicolas
Burrus, Vincent
author_facet Poulin-Laprade, Dominic
Carraro, Nicolas
Burrus, Vincent
author_sort Poulin-Laprade, Dominic
collection PubMed
description Nowadays, healthcare systems are challenged by a major worldwide drug resistance crisis caused by the massive and rapid dissemination of antibiotic resistance genes and associated emergence of multidrug resistant pathogenic bacteria, in both clinical and environmental settings. Conjugation is the main driving force of gene transfer among microorganisms. This mechanism of horizontal gene transfer mediates the translocation of large DNA fragments between two bacterial cells in direct contact. Integrative and conjugative elements (ICEs) of the SXT/R391 family (SRIs) and IncA/C conjugative plasmids (ACPs) are responsible for the dissemination of a broad spectrum of antibiotic resistance genes among diverse species of Enterobacteriaceae and Vibrionaceae. The biology, diversity, prevalence and distribution of these two families of conjugative elements have been the subject of extensive studies for the past 15 years. Recently, the transcriptional regulators that govern their dissemination through the expression of ICE- or plasmid-encoded transfer genes have been described. Unrelated repressors control the activation of conjugation by preventing the expression of two related master activator complexes in both types of elements, i.e., SetCD in SXT/R391 ICEs and AcaCD in IncA/C plasmids. Finally, in addition to activating ICE- or plasmid-borne genes, these master activators have been shown to specifically activate phylogenetically unrelated mobilizable genomic islands (MGIs) that also disseminate antibiotic resistance genes and other adaptive traits among a plethora of pathogens such as Vibrio cholerae and Salmonella enterica.
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spelling pubmed-45425802015-09-07 The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids Poulin-Laprade, Dominic Carraro, Nicolas Burrus, Vincent Front Microbiol Microbiology Nowadays, healthcare systems are challenged by a major worldwide drug resistance crisis caused by the massive and rapid dissemination of antibiotic resistance genes and associated emergence of multidrug resistant pathogenic bacteria, in both clinical and environmental settings. Conjugation is the main driving force of gene transfer among microorganisms. This mechanism of horizontal gene transfer mediates the translocation of large DNA fragments between two bacterial cells in direct contact. Integrative and conjugative elements (ICEs) of the SXT/R391 family (SRIs) and IncA/C conjugative plasmids (ACPs) are responsible for the dissemination of a broad spectrum of antibiotic resistance genes among diverse species of Enterobacteriaceae and Vibrionaceae. The biology, diversity, prevalence and distribution of these two families of conjugative elements have been the subject of extensive studies for the past 15 years. Recently, the transcriptional regulators that govern their dissemination through the expression of ICE- or plasmid-encoded transfer genes have been described. Unrelated repressors control the activation of conjugation by preventing the expression of two related master activator complexes in both types of elements, i.e., SetCD in SXT/R391 ICEs and AcaCD in IncA/C plasmids. Finally, in addition to activating ICE- or plasmid-borne genes, these master activators have been shown to specifically activate phylogenetically unrelated mobilizable genomic islands (MGIs) that also disseminate antibiotic resistance genes and other adaptive traits among a plethora of pathogens such as Vibrio cholerae and Salmonella enterica. Frontiers Media S.A. 2015-08-20 /pmc/articles/PMC4542580/ /pubmed/26347724 http://dx.doi.org/10.3389/fmicb.2015.00837 Text en Copyright © 2015 Poulin-Laprade, Carraro and Burrus. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Poulin-Laprade, Dominic
Carraro, Nicolas
Burrus, Vincent
The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids
title The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids
title_full The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids
title_fullStr The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids
title_full_unstemmed The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids
title_short The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids
title_sort extended regulatory networks of sxt/r391 integrative and conjugative elements and inca/c conjugative plasmids
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542580/
https://www.ncbi.nlm.nih.gov/pubmed/26347724
http://dx.doi.org/10.3389/fmicb.2015.00837
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